Average excluded-volume crowding effect, which alone stabilizes dimers relative to separated monomers
| Value | 1.1 kcal/mol Range: ±0.3 kcal/mol |
|---|---|
| Organism | Generic |
| Reference | McGuffee SR, Elcock AH. Diffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasm. PLoS Comput Biol. 2010 Mar 5 6(3):e1000694. p.7 right column bottom paragraphPubMed ID20221255 |
| Comments | "For the formation of homo-dimeric complexes (Figure 4E), [researchers] again find that the excluded-volume crowding effect, which alone stabilizes dimers relative to separated monomers by on average 1.1±0.3 kcal/mol, is largely cancelled by the more favorable energetic interactions that the monomers form with the cytoplasm constituents: when the ‘full’ energy model is used the stabilization of the dimeric forms by the cytoplasm is computed to be, on average, only 0.1±0.3 kcal/mol." |
| Entered by | Uri M |
| ID | 108470 |