Average protein half-life

Value 23 Hours Range: 12 to 42 Hours
Organism Bacteria Mycoplasma pneumoniae
Reference Maier T, Schmidt A, Güell M, Kühner S, Gavin AC, Aebersold R, Serrano L. Quantification of mRNA and protein and integration with protein turnover in a bacterium. Mol Syst Biol. 2011 Jul 19 7: 511. doi: 10.1038/msb.2011.38. p.5 left column 2nd paragraphPubMed ID21772259
Method "...[researchers] measured genome-wide individual protein turnover rates using a label-chase approach involving stable isotope-labelled amino acids."
Comments "[Researchers] obtained longer protein half-lives, averaging 23 h. Most of the determined protein half-lives span from 12 h (10th percentile) to 42 h (90th percentile) (Figure 3A)."
Entered by Uri M
ID 108350