Percent of triploids out of total conceptions

Range 1-3 %
Organism Human Homo sapiens
Reference McFadden DE, Kwong LC, Yam IY, Langlois S. Parental origin of triploidy in human fetuses: evidence for genomic imprinting. Hum Genet. 1993 Nov92(5):465-9.PubMed ID7902318
Primary Source Jacobs PA, Angell RR, Buchanan IM, Hassold TJ, Matsuyama AM, Manuel B. The origin of human triploids. Ann Hum Genet. 1978 Jul42(1):49-57.PubMed ID686684
Comments Triploidy is a chromosomal abnormality, which is estimated to occur in 1%-3% of recognized human conceptions. It consists of the presence of an extra haploid set of chromosomes for a total, in humans, of 69 chromosomes. Polyspermy is the most common mechanism leading to human triploids (Otto et al 2000, PMID 11092833), and according to primary source: The best fit for the data using a maximum-likelihood method was that 66.4% of the triploids were the result of dispermy, 23.6% the result of fertilization of a haploid ovum by a diploid sperm formed by failure of the first meiotic division in the male and 10% the result of a diploid egg formed by failure of the first maternal meiotic division.
Entered by Uri M
ID 105419