|Field Y, Kaplan N, Fondufe-Mittendorf Y, Moore IK, Sharon E, Lubling Y, Widom J, Segal E. Distinct modes of regulation by chromatin encoded through nucleosome positioning signals. PLoS Comput Biol. 2008 Nov4(11): fig. 2A, fig. 2SPubMed ID18989395
|To obtain a single molecule map of yeast nucleosomes, researchers isolated mononucleosomes from eight independent biological replicates and fully sequenced ~503,000 of the nucleosome DNAs, using a parallel sequencing technology whose sequence reads are ~200 bp long.
|several studies characterized the nucleosomes' intrinsic sequence preferences primarily by ~10 bp periodicities of specific dinucleotides along the nucleosome length, thought to facilitate the sharp bending of DNA around the nucleosome.