| Range |
~2 weeks of age of granule cell
|
| Organism |
Mouse Mus musculus |
| Reference |
Josselyn SA, Frankland PW. Infantile amnesia: a neurogenic hypothesis. Learn Mem. 2012 Aug 16 19(9):423-33. doi: 10.1101/lm.021311.110 p.430 left column bottom paragraphPubMed ID22904373
|
| Primary Source |
Zhao C et al., Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci. 2006 Jan 4 26(1):3-11 DOI: 10.1523/JNEUROSCI.3648-05.2006 AND Toni N et al., Synapse formation on neurons born in the adult hippocampus. Nat Neurosci. 2007 Jun10(6):727-34 DOI: 10.1038/nn1908 AND Toni N et al., Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci. 2008 Aug11(8):901-7. doi: 10.1038/nn.2156PubMed ID16399667, 17486101, 18622400
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| Method |
Primary source Zhao et al. abstract: "By using retrovirus-mediated gene transduction, [investigators] followed the dendritic and axonal growth of adult-born neurons in the mouse dentate gyrus and identified distinct morphological stages that may indicate different levels of connectivity." Primary source Toni et al. 2007 abstract: "Here [investigators] explored the mechanisms of synaptogenesis on neurons born in the adult mouse hippocampus using confocal microscopy, electron microscopy and live imaging." Primary source Toni et al. 2008 abstract: "By combining retroviral expression of green fluorescent protein in adult-born neurons of the mouse dentate gyrus with immuno-electron microscopy, [investigators] found output synapses that were formed by labeled terminals on appropriate target cells in the CA3 [Cornu Ammonis region 3 (in hippocampus)] area and the hilus. Furthermore, retroviral expression of channelrhodopsin-2 allowed [them] to light-stimulate newborn granule cells and identify postsynaptic target neurons by whole-cell recordings in acute slices." |
| Comments |
P.430 left column bottom paragraph: "The two phases of neurogenesis depend on the age of the adult-generated neurons. Shortly after they are born, newly generated granule cells migrate into the granule cell layer of the DG, and by ∼2 wk they begin to make functional afferent and efferent connections (primary sources)." |
| Entered by |
Uri M |
| ID |
117233 |