Time interval over which cerebral cortex folding largely occurs

Range in ferrets postnatal day (P)10 to P30: in rhesus macaques gestation days (G)90 to G135: in humans from the 25th week of gestation to a postnatal age of 4 months Table - link
Organism Mammals
Reference Kroenke CD, Bayly PV. How Forces Fold the Cerebral Cortex. J Neurosci. 2018 Jan 24 38(4):767-775. doi: 10.1523/JNEUROSCI.1105-17.2017 p.770 figure 2 and p.772 left column bottom paragraph and right column top paragraphPubMed ID29367287
Primary Source Knutsen AK et al., Spatial and temporal variations of cortical growth during gyrogenesis in the developing ferret brain. Cereb Cortex. 2013 Feb23(2):488-98. doi: 10.1093/cercor/bhs042 AND Wang X et al., Folding, But Not Surface Area Expansion, Is Associated with Cellular Morphological Maturation in the Fetal Cerebral Cortex. J Neurosci. 2017 Feb 22 37(8):1971-1983. doi: 10.1523/JNEUROSCI.3157-16.2017PubMed ID22368085, 28069920
Method Primary source Knutsen et al.: "Spatial and temporal variations in cortical growth were studied in the neonatal ferret to illuminate the mechanisms of folding of the cerebral cortex. Cortical surface representations were created from magnetic resonance images acquired between postnatal day 4 and 35." Primary source Wang et al.: "Altered macroscopic anatomical characteristics of the cerebral cortex have been identified in individuals affected by various neurodevelopmental disorders. However, the cellular developmental mechanisms that give rise to these abnormalities are not understood. Previously, advances in image reconstruction of diffusion magnetic resonance imaging (MRI) have made possible high-resolution in utero measurements of water diffusion anisotropy in the fetal brain. Here, diffusion anisotropy within the developing fetal cerebral cortex is longitudinally characterized in the rhesus macaque, focusing on gestation day (G85) through G135 of the 165 d term. Additionally, for subsets of animals characterized at G90 and G135, immunohistochemical staining was performed, and 3D structure tensor analyses were used to identify the cellular processes that most closely parallel changes in water diffusion anisotropy with cerebral cortical maturation."
Comments P.772 left column bottom paragraph: "Figure 2 provides a timeline of brain development over the period in which folding takes place. As documented previously (primary sources), folding largely occurs over the interval from postnatal day (P)10 to P30 in ferrets, gestation days (G)90 to G135 in rhesus macaques, and in humans from the 25th week of gestation to a postnatal age of 4 months. Immediately before folding, surface area expansion is approximately threefold slower than it is during the period in which folding occurs (primary sources)."
Entered by Uri M
ID 117215