| Range |
~1.5 unitless
|
| Organism |
Guinea Pig Cavia porcellus |
| Reference |
Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan88(1):173-210. doi: 10.1152/physrev.00044.2006 p.187 left column 2nd paragraphPubMed ID18195086
|
| Primary Source |
[109] Gale JE, Ashmore JF. An intrinsic frequency limit to the cochlear amplifier. Nature. 1997 Sep 4 389(6646):63-6 DOI: 10.1038/37968 [294] Santos-Sacchi J, Huang G. Temperature dependence of outer hair cell nonlinear capacitance. Hear Res. 1998 Feb116(1-2):99-106PubMed ID9288966, 9508032
|
| Method |
Primary source [109] abstract: "The cochlear amplifier operates up to at least 22 kHz, but by measuring both the charge and mechanical movements associated with the motor in isolated membrane patches under voltage clamp, [investigators] show here that the limiting frequency at which the motor operates lies near 25 kHz." Primary source [294] abstract: "The temperature dependence of outer hair cell motility-related gating current and capacitance was evaluated under whole-cell voltage clamp." |
| Comments |
P.187 left column 2nd paragraph: "The underlying rate of lengthening and of the charge movement of OHC motility is weakly temperature dependent (ref 16). The kinetics of the charge movement has a temperature Q10 of ∼1.5 both in membrane patches (primary source 109) and in whole cell recording (primary source 294), pointing to a relatively simple underlying physical mechanism." Primary source [294] abstract: "Gating current kinetics showed only mild temperature dependence, the Q10 being about 1.5." |
| Entered by |
Uri M |
| ID |
117136 |