| Range |
~100 µm/sec
|
| Organism |
Unspecified |
| Reference |
Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006 Jan7(1):41-53 DOI: 10.1038/nrn1824 p.47 left column 2nd paragraphPubMed ID16371949
|
| Primary Source |
[78] Cornell-Bell AH, Finkbeiner SM, Cooper MS, Smith SJ. Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science. 1990 Jan 26 247(4941):470-3 DOI: 10.1126/science.1967852 [79] Blomstrand F et al., 5-Hydroxytryptamine and glutamate modulate velocity and extent of intercellular calcium signalling in hippocampal astroglial cells in primary cultures. Neuroscience. 1999 88(4):1241-53 DOI: 10.1016/s0306-4522(98)00351-0PubMed ID1967852, 10336133
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| Method |
Primary source [79] abstract: "The effects of 5-hydroxytryptamine or glutamate treatment on mechanically induced intercellular calcium waves were studied in gap junction-coupled astroglial cells using rat astroglial-neuronal primary cultures from hippocampus. Imaging software was developed to study amplitude, velocity and extent of wave propagation. Velocity software was designed to find the cell contours automatically and to calculate travelled distance and time-delay of the calcium wave as it propagates from the stimulated cell to all other cells. Propagation analyses were performed to calculate the area of wave propagation." |
| Comments |
P.47 left column 2nd paragraph: "The spread of calcium waves through the astrocytic syncytium, propagating at a rate of ∼100μm/s, can be triggered by activation of 5-hydroxytryptamine (5-HT, serotonin) or glutamate receptors, or mechanical stimulation (primary sources)." Primary source [79] studied rats |
| Entered by |
Uri M |
| ID |
117116 |