Fraction of the transcriptome (including many essential genes), that is expressed at less than 2 copies per cell

Value 80 %
Organism Budding yeast Saccharomyces cerevisiae
Reference Zenklusen D, Larson DR, Singer RH. Single-RNA counting reveals alternative modes of gene expression in yeast.Nat Struct Mol Biol. 2008 Dec15(12):1263-71. p.1263 left column bottom paragraphPubMed ID19011635
Primary Source [12] Holstege FC et al., Dissecting the regulatory circuitry of a eukaryotic genome. Cell. 1998 Nov 25 95(5):717-28PubMed ID9845373
Method Primary source abstract: "Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast."
Comments P.1263 left column bottom paragraph: "High-throughput analyses in yeast showed that protein variation for most genes is low [ref 11]. However, in the yeast Saccharomyces cerevisiae, most mRNAs are present in low abundance: 80% of the transcriptome, including many essential genes, are expressed at less than two copies per cell [primary source]."
Entered by Uri M
ID 117022