Average number of target genes for each of the 67 transcription factors analyzed

Value 124 target genes
Organism Fruit fly Drosophila melanogaster
Reference Carroll SB. Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Cell. 2008 Jul 11 134(1):25-36. doi: 10.1016/j.cell.2008.06.030 p.30 right column top paragraphPubMed ID18614008
Primary Source Stark A et al., Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature. 2007 Nov 8 450(7167):219-32 DOI: 10.1038/nature06340PubMed ID17994088
Method Primary source abstract: "Sequencing of multiple related species followed by comparative genomics analysis constitutes a powerful approach for the systematic understanding of any genome. Here, [investigators] use the genomes of 12 Drosophila species for the de novo discovery of functional elements in the fly."
Comments P.30 right column top paragraph: "For example, Stark et al. (primary source) estimated that there are, on average, 124 target genes for each of the 67 Drosophila transcription factors they analyzed."
Entered by Uri M
ID 117005