Volume of alveolar macrophage (AM) in normal rat

Value 1170 µm^3 Range: 400 - 5000 µm^3
Organism Rat Rattus norvegicus
Reference Haley PJ, Muggenburg BA, Weissman DN, Bice DE. Comparative morphology and morphometry of alveolar macrophages from six species. Am J Anat. 1991 Aug191(4):401-7 DOI: 10.1002/aja.1001910407 p.403 right column 2nd paragraphPubMed ID1951138
Primary Source Strom KA. Response of pulmonary cellular defenses to the inhalation of high concentrations of diesel exhaust. J Toxicol Environ Health. 1984 13(4-6):919-44 DOI: 10.1080/15287398409530551PubMed ID6208373
Method P.403 right column 2nd paragraph: "Strom (primary source) using an electronic particle counter coupled to a multichannel analyzer, reported that alveolar macrophages of normal rats ranged in size from 400-5,000 µm^3, with a mean of 1,170 µm^3." Primary source abstract: "The cell numbers and volumes were measured using an electronic particle counter."
Comments Primary source abstract: "The geometric mean volumes of AM from the exposed and control animals were approximately 1100 µm^3 at both 6 and 12 mo of exposure, although exposed cell-volume distributions skewed towards larger sizes."
Entered by Uri M
ID 116929