| Comments |
P.1805 left column bottom paragraph: "In humans, mtDNA is a circular 16,569 bp molecule (Figure 1) which encodes 37 “formal” genes: 13 polypeptides and 24 RNA components of the mitochondrial translational apparatus (2 rRNAs and 22 tRNAs). mtDNA is characterized by a tight packaging of genetic information: mitochondrial genes in mammals lack introns, and intergenic sequences are either absent or limited to a few bases." P.1805 right column bottom paragraph: "In recent years, it became increasingly apparent that in addition to its 37 “formal” genes, mtDNA may encode short open reading frames (ORFs) which can be translated into peptides with important biological functions." Please see Kukat et al., 2011 PMID 21808029 p.13534 left column: "The mammalian mtDNA is a highly compacted genome of∼16.5kb and is very gene-dense, despite its small size, encoding 13 proteins, 2 ribosomal RNAs, and 22 tRNAs (refs 4, 5 therein)." |