Fraction of disordered proteins in proteome

Range bacteria ~5%: higher eukaryotes ~30-50 %
Organism Various
Reference Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6672 left column bottom paragraphPubMed ID24901537
Primary Source [253] Edwards YJ, Lobley AE, Pentony MM, Jones DT. Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol. 2009 10(5):R50. doi: 10.1186/gb-2009-10-5-r50PubMed ID19432952
Comments P.6672 left column bottom paragraph: "Although bacteria have fewer disordered proteins in their proteomes (∼5%) than higher eukaryotes (∼30-50%), their prominence in copius cellular factors such as ribosomal proteins, transcriptional regulators and chaperones (primary source) renders IDP [intrinsically disordered proteins] mRNAs more abundant than transcripts of folded proteins."
Entered by Uri M
ID 116234