| Range |
Table - link amol/cell/sec
|
| Organism |
Mammals |
| Reference |
Wagner BA, Venkataraman S, Buettner GR. The rate of oxygen utilization by cells. Free Radic Biol Med. 2011 Aug 1 51(3):700-12. doi: 10.1016/j.freeradbiomed.2011.05.024 p.709 table 4PubMed ID21664270
|
| Primary Source |
[72] Herst PM, Berridge MV. Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochim Biophys Acta. 2007 Feb1767(2):170-7 DOI: 10.1016/j.bbabio.2006.11.018PubMed ID17266920
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| Comments |
P.708 right column top paragraph: "Allometry of mammalian cell OCR: Oxygen consumption is not associated just with the electron transport chain of mitochondria. In addition to mitochondrial respiration, cells consume oxygen during other processes. Herst and Berridge [primary source] have examined nonmitochondrial oxygen consumption and found it to vary widely in various cell types (Table 4). The enzymes responsible for this observed “cell-surface” oxygen consumption have not been fully identified. Although NADPH-oxidases are one route for this mode of oxygen consumption, this seems not to be the case for HL-60ρ0 cells. These investigators suggest that this trans-plasma membrane electron transport results from the oxidation of NADH. This oxidation not only will facilitate glycolysis, but also contributes to acidification of the medium: these processes are proposed to intercede to ameliorate reductive stress. They found that cell-surface oxygen consumption contributes significantly to total cellular oxygen consumption, not only in ρ0 cells, but also in mitochondrially competent tumor cell lines." amol=atto mol=10^-18moles. NAD=Nicotinamide adenine dinucleotide. NADPH=reduced form of Nicotinamide adenine dinucleotide phosphate |
| Entered by |
Uri M |
| ID |
115505 |