| Comments |
P.224 2nd paragraph: "Because the proposed nomenclature system relies on establishing homologies across miRNA genes in five key vertebrate taxa (Supplemental Table 3), the evolutionary history of the entire microRNAome of virtually any species of osteichthyan (i.e., bony fish) (including human) can be reconstructed. Figure 5 shows this history for every known miRNA in the human, chicken, fish, fruit fly, C. elegans, and nudibranch lineages. In human, 318 miRNA gene families consisting of 585 genes have appeared in the ∼800 million years since divergence from sponges (see Supplemental Table 4 for a list of genes for each node indicated on the figure). These genes were acquired continuously over time, with nearly every branching point analyzed in the topology characterized by the addition of at least one new miRNA gene (ref 144)." Updated annotation from Fromm et al (2015). See link |