| Comments |
P.8 bottom paragraph: "Given the demand-based working model described above, [investigators] assume that one or more “household” ribonucleases (RNases) are responsible for tRNA degradation during amino acid starvation, maybe aided by a factor that stimulates ribonucleolytic attack on the tRNA either by modification of the tRNA substrate or by up-regulation of RNase activity. The E. coli genome encodes more than 20 ribonucleases, including a number that participate in the processing of precursor transcripts to generate mature tRNAs, such as RNase E, RNase P, RNase PH and RNase T (reviewed in refs. 32, 33)." |