Number of multipotent progenitors (MPPs), circulating T lineage-committed progenitors, & common lymphoid progenitors (CLPs) in blood

Range MPPs ~180: circulating T lineage-committed progenitors 600: CLPs 180
Organism Mouse Mus musculus
Reference Krueger A, Ziętara N, Łyszkiewicz M. T Cell Development by the Numbers. Trends Immunol. 2017 Feb38(2):128-139. doi: 10.1016/ p.130 bottom paragraphPubMed ID27842955
Primary Source See link
Comments P.130 bottom paragraph: "The numbers of candidate TSPs [thymus-seeding progenitors] circulating in peripheral blood are extremely small. Thus, blood from a mouse contains approximately 180 MPPs, 600 circulating T lineage-committed progenitors, and 180 CLPs [primary sources]. It remains to be established whether progenitor numbers in peripheral blood are actively maintained through controlled release from BM [bone marrow] or passively due to a lack of survival factors [ref 23]. The residence time of HSCs [hematopoietic stem cells] and progenitors in circulation was estimated to be in the range of only 6 min, suggesting that peripheral blood does not constitute a conductive environment for BM-derived progenitors [BNID 113823]."
Entered by Uri M
ID 113822