Estimated overall efficiency of peptide generation for MHC class I molecules is on the order of

Value 1 per 10,000 proteins degraded
Organism Unspecified
Reference Yewdell JW, Reits E, Neefjes J. Making sense of mass destruction: quantitating MHC class I antigen presentation. Nat Rev Immunol. 2003 Dec3(12):952-61. DOI: 10.1038/nri1250 p.959 right column top paragraphPubMed ID14647477
Primary Source [48] Yewdell, J. W. Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing. Trends Cell Biol. 11, 294–297 (2001) p.296 right column 2nd paragraphPubMed ID11413040
Comments P.959 right column top paragraph: "Moreover, the SIINFEKL [OVA257-264] peptide might be generated more efficiently than the average determinant: inasmuch as peptides are limiting for MHC class I assembly [ref 73], the overall efficiency of peptide generation for MHC class I molecules can be estimated to be in the order of 1 per 10,000 proteins degraded [primary source]."
Entered by Uri M
ID 113820