Fraction of newly synthesized cystic fibrosis transmembrane conductance proteins destroyed by proteasomes
| Value | 70 % |
|---|---|
| Organism | Unspecified |
| Reference | Yewdell JW, Reits E, Neefjes J. Making sense of mass destruction: quantitating MHC class I antigen presentation. Nat Rev Immunol. 2003 Dec3(12):952-61. DOI: 10.1038/nri1250 p.958 left column bottom paragraphPubMed ID14647477 |
| Primary Source | [58] Jensen, T. J. et al. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83, 129–135 (1995) [59] Ward, C. L., Omura, S. & Kopito, R. R. Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83, 121–127 (1995)PubMed ID7553864, 7553863 |
| Comments | P.958 left column 3rd paragraph: "Seventy percent of newly synthesized cystic fibrosis transmembrane conductance protein is destroyed by proteasomes [primary sources], whereas 80% of peripheral myelin protein 22 synthesized by Schwann cells is destroyed within an hour of its synthesis [BNID 113777], probably by proteasomes [ref 61]." |
| Entered by | Uri M |
| ID | 113776 |