| Range |
Table - link days
|
| Organism |
Human Homo sapiens |
| Reference |
Darwich AS, Aslam U, Ashcroft DM, Rostami-Hodjegan A. Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. Drug Metab Dispos. 2014 Dec42(12):2016-22. doi: 10.1124/dmd.114.058404 supplementary data pp.16-17 table 3PubMed ID25233858
|
| Primary Source |
See pointers to refs in right column of table |
| Method |
Abstract: "Current physiologically based pharmacokinetic (PBPK) models consider enzyme and enterocyte recovery as a lumped first-order rate. An assessment of enterocyte turnover would enable enzyme and enterocyte renewal to be modeled more mechanistically. A
literature review together with statistical analysis was employed
to establish enterocyte turnover in human and preclinical species." See "Method" column in table |
| Comments |
P.2019 left column 2nd paragraph: "The literature search for human enterocyte turnover data identified 17 studies, with a total sample size of 265 individuals (Supplemental Table 3), reporting the turnover of human GI [gastrointestinal] epithelial cells in the form of mean and S.D. (n = 86), mean only (n = 153), and ranges (n = 26). The majority of turnover values were from colonic, rectal (n = 157), duodenal (n = 60), and gastric epithelial cells (n = 36),
whereas jejunum and ileum were limited to sample sizes of 3 and 9, respectively." |
| Entered by |
Uri M |
| ID |
113699 |