| Range |
Table - link days
|
| Organism |
Mouse Mus musculus |
| Reference |
Darwich AS, Aslam U, Ashcroft DM, Rostami-Hodjegan A. Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. Drug Metab Dispos. 2014 Dec42(12):2016-22. doi: 10.1124/dmd.114.058404 supplementary data pp.13-15 table 2PubMed ID25233858
|
| Primary Source |
See pointers to refs in right column of table |
| Method |
Abstract: "Current physiologically based pharmacokinetic (PBPK) models consider enzyme and enterocyte recovery as a lumped first-order rate. An assessment of enterocyte turnover would enable enzyme and enterocyte renewal to be modeled more mechanistically. A
literature review together with statistical analysis was employed
to establish enterocyte turnover in human and preclinical species." See "Method" column in table |
| Comments |
P.2018 right column bottom paragraph: "In the mouse, a total of 31 studies consisting of 651 healthy adult mice was identified reporting the enterocyte turnover in the small intestinal epithelia (Supplemental Table 2). The geometric WX [weighted mean] enterocyte turnover for the GI [gastrointestinal] tract was 2.81 (61.14, n = 169 mice) days." |
| Entered by |
Uri M |
| ID |
113698 |