| Range |
Table - link days
|
| Organism |
Rat Rattus norvegicus |
| Reference |
Darwich AS, Aslam U, Ashcroft DM, Rostami-Hodjegan A. Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. Drug Metab Dispos. 2014 Dec42(12):2016-22. doi: 10.1124/dmd.114.058404 supplementary data pp.8-12 table 1PubMed ID25233858
|
| Primary Source |
See pointers to refs in right column of table |
| Method |
Abstract: "Current physiologically based pharmacokinetic (PBPK) models consider enzyme and enterocyte recovery as a lumped first-order rate. An assessment of enterocyte turnover would enable enzyme and enterocyte renewal to be modeled more mechanistically. A
literature review together with statistical analysis was employed
to establish enterocyte turnover in human and preclinical species." See "Method" column in table |
| Comments |
P.2018 left column bottom paragraph: "The literature search of enterocyte turnover in healthy adult subjects
of preclinical species identified a total of 68 studies (n subjects =
1337). In the rat, 24 studies consisting of 501 subjects were identified
(Supplemental Table 1), in which the arithmetic WX [weighted mean] GI [gastrointestinal] enterocyte turnover was determined to be 2.37 days." |
| Entered by |
Uri M |
| ID |
113697 |