| Range |
5 errors per 10,000 codons translated
|
| Organism |
Unspecified |
| Reference |
Drummond DA, Bloom JD, Adami C, Wilke CO, Arnold FH. Why highly expressed proteins evolve slowly. Proc Natl Acad Sci U S A. 2005 Oct 4 102(40):14338-43. DOI: 10.1073/pnas.0504070102 p.14341 left column 2nd paragraphPubMed ID16176987
|
| Primary Source |
[35] Parker J. Errors and alternatives in reading the universal genetic code. Microbiol Rev. 1989 Sep53(3):273-98.PubMed ID2677635
|
| Comments |
P.14341 left column 2nd paragraph: "[Investigators] advance a third hypothesis based on a simple observation: to reduce the number of proteins that misfold due to translation errors, selection can act both on the nucleotide sequence, to increase translational accuracy by optimizing codon usage (ref 34), and on the amino acid sequence, to increase the number of proteins that fold properly despite mistranslation (Fig. 3). [They] call this increased tolerance for translational missense errors ‘‘translational robustness.’’ At the canonical ribosomal error rate of 5 errors per 10,000 codons translated (primary source), ≈19% of average length yeast proteins (415 aa) contain a missense error, and these errors may cause misfolding (ref 36)." |
| Entered by |
Uri M |
| ID |
113374 |