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Fraction of the whole cell Ca2+ current carried by N channel (N-type calcium channel)

Range	pig ≤80%: cat 45%: bovine, rat, mouse & human chromaffin cells 30% % of the whole cell Ca2+ current
Organism	Mammals
Reference	García AG et al., Calcium signaling and exocytosis in adrenal chromaffin cells. Physiol Rev. 2006 Oct86(4):1093-131. DOI: 10.1152/physrev.00039.2005 p.1098 right column 2nd paragraphPubMed ID17015485
Primary Source	[5] Albillos A et al., Calcium channel subtypes in cat chromaffin cells. J Physiol 477: 197–213, 1994. [158] Gandia L, Borges R, Albillos A, and Garcia AG. Multiple calcium channel subtypes in isolated rat chromaffin cells. Pflügers Arch 430: 55–63, 1995. [162] Gandía L et al. Human adrenal chromaffin cell calcium channels: drastic current facilitation in cell clusters, but not in isolated cells. Pflugers Arch. 1998 Oct436(5):696-704. DOI: 10.1007/s004240050691 [191] Hernandez-Guijo JM, de Pascual R, Garcia AG, and Gandia L. Separation of calcium channel current components in mouse chromaffin cells superfused with low- and high-barium solutions. Pflügers Arch 436: 75–82, 1998. DOI: 10.1007/s004240050606 [226] Kitamura N, Ohta T, Ito S, and Nakazato Y. Calcium channel subtypes in porcine adrenal chromaffin cells. Pflügers Arch 434: 179–187, 1997. DOI: 10.1007/s004240050381 [249] López MG et al., Q- and L-type Ca2+ channels dominate the control of secretion in bovine chromaffin cells. FEBS Lett. 1994 Aug 8 349(3):331-7.PubMed ID7523660, 7545281, 9716702, 9560449, 9136672, 8050592
Comments	P.1098 right column 2nd paragraph: "The N channel also shows a high interspecies variability. In the pig it carries as much as 80% of the whole cell calcium channel current (primary source 226) and 45% in the cat (primary source 5) in bovine (primary source 249), rat (primary source 158), mouse (primary source 191) and human chromaffin cells (primary source 162) the N-type fraction accounts for 30% of the whole cell calcium channel current."
Entered by	Uri M
ID	113139