Lipid composition of peroxisomal membrane of oleate-grown S. cerevisiae

Range phosphatidylcholine 48.2%: phosphatidylethanolamine 22.9%: phosphatidylinositol 15.8%:cardiolipin 7% %
Organism Budding yeast Saccharomyces cerevisiae
Reference Kohlwein SD, Veenhuis M, van der Klei IJ. Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fatstore 'em up or burn 'em down. Genetics. 2013 Jan193(1):1-50. doi: 10.1534/genetics.112.143362. p.18 right column 4th paragraphPubMed ID23275493
Primary Source Zinser E et al. Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae. J Bacteriol. 1991 Mar173(6):2026-34.PubMed ID2002005
Comments P.18 right column 4th paragraph: "The lipid composition of oleate-grown S. cerevisiae peroxisomes has been determined by Zinser et al. (primary source). The peroxisomal membrane contains the major cellular phospholipids—phosphatidylcholine (48.2%), phosphatidylethanolamine (22.9%), and phosphatidylinositol (15.8%)—but also has a remarkably high cardiolipin content (7%). The relative abundance of cardiolipin is noteworthy since this lipid is synthesized in mitochondria (Henry et al. 2012). The other lipids are derived from the ER-however, the mechanisms by which these lipids reach the peroxisomes are not yet firmly established-some evidence suggests that this process involves vesicular transport both from the ER and from mitochondria (Braschi et al. 2010)."
Entered by Uri M
ID 113112