| Comments |
P.25 left column bottom paragraph to right column top paragraph: "The contribution of the endocrine pancreas to glucose homeostasis: The pancreas is a dual function organ composed of both exocrine and endocrine glands [ref 1]. The exocrine portion of the pancreas supports digestion by secreting pancreatic juices containing digestive enzymes into the small intestine. The endocrine portion of the pancreas, composed of the islets of Langerhans, is a nutrient-sensing organ critical in the maintenance of glucose homeostasis that secretes hormones as a rapid response to changing blood glucose levels. These pancreatic islets are vascularized spheroid clusters of endocrine cells scattered throughout the pancreas, comprising only about 1% of its mass. They are composed of several main endocrine cell types, including α-, β-, δ-, ε- and PP-cells (gamma cells), which work in concert to regulate blood glucose [ref 2]." |