Fraction of endothelial cells which turnover daily that undergo proliferation in normal tissue

Range 0.1-3.0 %
Organism Rat Rattus norvegicus
Reference Raluca BA et al., Endothelial Cell Proliferation and Vascular Endothelial Growth Factor Expression in Primary Colorectal Cancer and Corresponding Liver Metastases. Asian Pac J Cancer Prev. 2015 16(11):4549-53. p.4549 left columnPubMed ID26107202
Primary Source Schwartz SM, Benditt EP (1973). Cell replication in the aortic endothelium: A new method for study of the problem. Lab Invest, 28, 699-707PubMed ID4576806
Method Primary source abstract: "This paper presents a procedure for mapping the distribution of replicating cells on the aortic surface and for quantitatively determining the rate of aortic endothelial cell replication using a new method of preparing the endothelium for 3H thymidine autoradiography. Data from 3 month old rats show a relatively low rate of replication, approximately 0.3% to 1.5% of the population entering DNA synthesis each day."
Comments P.4549 left column: "Normal tissues are characterized by the presence of blood and lymphatic vessels lined by endothelial cells exhibiting a low proliferation rate ranged between 0.1- 3% of all endothelial cells which turnover daily but this percentage decline with age (primary source)." Primary source studied rats
Entered by Uri M
ID 112747