| Comments |
P.1300 left column bottom paragraph: "Several other features of the chemotaxis pathway reflect a pressure toward rapidity. First, the existence of a dedicated phosphatase for the response regulator CheY, which is uncommon for two-component systems, suggests the importance of fast turnover of the CheY-P pool. Second, CheA is an extremely fast histidine kinase: when incorporated in signaling complexes containing chemoreceptors and CheW, the autocatalytic rate of CheA is kcatA=20/s for E. coli (refs 52, 53 and 54) and Salmonella typhimurium (primary source 29), which makes it four to five orders of magnitude faster than other kinases in two-component systems (Table S3)." See note above table |