| Value |
115
days
Range: 70 - 140 days
|
| Organism |
Human Homo sapiens |
| Reference |
Franco RS. Measurement of red cell lifespan and aging. Transfus Med Hemother. 2012 Oct39(5):302-7. doi: 10.1159/000342232. p.302 right column top paragraphPubMed ID23801920
|
| Primary Source |
[1] Cohen RM et al., Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c. Blood 2008 112: 4284–4291. doi: 10.1182/blood-2008-04-154112. [2] Mock DM et al., Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities. Transfusion 2011 51: 1047–1057. doi: 10.1111/j.1537-2995.2010.02926.x.PubMed ID18694998, 21062290
|
| Comments |
P.302 left column: "Human red blood cells (RBC), after differentiating from
erythroblasts in the bone marrow, are released into the blood and survive in the circulation for approximately 115 days. In humans and some other species, RBC normally survive in a nonrandom manner. This means that all of the RBC in an age cohort are removed by the reticuloendothelial system at about
the same time. In practice there is considerable variation in the lifespan of human RBC. In a normal individual with a mean RBC lifespan of 115 days, this value may vary between 70 and 140 days [primary sources 1, 2]. Among individuals the mean lifespan varies by approximately ±15% [primary source 1]. As discussed below, there are circumstances in which even this relatively small normal variation can be important." |
| Entered by |
Uri M |
| ID |
112478 |