| Comments |
P.3354 left column bottom paragraph: "Correlation between the biomarkers and the mitochondrial fractional area: Several biomarkers showed a strong correlation and high concordance with mitochondrial fractional area. The correlation coefficients, P values and Lin concordance coefficients can be seen in Table 2 where the biomarkers are listed according to their Rc rank to the mitochondrial fractional area. Cardiolipin content had the strongest correlation and highest Rc value of 0.85 defined as an ‘almost perfect concordance’ (Lin, 1989 Fig. 3A)." P.3355 left column 2nd paragraph:"The cristae surface area was significantly correlated with the same biomarkers as the mitochondrial content (Table 2). The biomarker that showed the strongest concordance with cristae surface area was complex I activity (Rc= 0.71) and complex II protein content (Rc= 0.71), followed by complex V protein content (Rc= 0.70), cardiolipin content (Rc= 0.67), CS [citrate synthase] activity (Rc= 0.67) and complex IV activity (Rc= 0.64). As can be seen in Table 2, the concordance was generally lower between the biomarkers and the cristae surface area when compared with mitochondrial surface area." See notes beneath table |