Total number of vesicles in neuromuscular junction

Range ~500,000 vesicles
Organism Frog Rana pipiens
Reference Rizzoli SO, Betz WJ. Synaptic vesicle pools. Nat Rev Neurosci. 2005 Jan6(1):57-69. P.59 right column 4th paragraphPubMed ID15611727
Primary Source [25] Heuser, J. E. & Reese, T. S. Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction. J. Cell Biol. 57, 315–344 (1973) [35] Ceccarelli, B., Hurlbut, W. P. & Mauro, A. Turnover of transmitter and synaptic vesicles at the frog neuromuscular junction. J. Cell Biol. 57 ,499–524 (1973). [36] Molgo, J. & Pecot-Dechavassine, M. Effects of carbonyl cyanide m-chlorophenylhydrazone on quantal transmitter release and ultrastructure of frog motor nerve terminals. Neuroscience 24, 695–708 (1988).PubMed ID4348786, 4348791, 2834667
Comments P.59 right column 4th paragraph: "Frog neuromuscular junction: In the cutaneous pectoris and sartorius NMJs of the frog (Rana pipiens) (FIG. 3), the total vesicle pool contains ~500,000 vesicles [primary sources]. An initial phase of release (from the RRP [Readily releasable pool]) is exhausted within ~0.5 s of high-frequency stimulation [ref 8]: these vesicles make up ~2% of the total pool [ref 37]."
Entered by Uri M
ID 112454