Fraction of cell volume occupied by the 1,000-fold compacted DNA molecule

Range ~15 %
Organism bacteria
Reference Soler-Bistué A et al., Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity. PLoS Genet. 2015 Apr 13 11(4):e1005156. doi: 10.1371/journal.pgen.1005156. p.2/21 2nd paragraphPubMed ID25875621
Primary Source [1] Reyes-Lamothe R, Nicolas E, Sherratt DJ. Chromosome replication and segregation in bacteria. Annual review of genetics. 2012 46:121–43. doi: 10.1146/annurev-genet-110711-155421PubMed ID22934648
Comments P.2/21 2nd paragraph:"The bacterial genome consists of a DNA molecule which is compacted 1000-fold to occupy about 15% of the cell volume [primary source 1]. The genome is precisely organized within such a limited cellular space to ensure that DNA replication, segregation and gene expression are well orchestrated [primary source 1, refs 2,3]. Bioinformatics studies suggest that gene order within the chromosome contribute to the spatial organization of the DNA molecule and may optimize bacterial physiology [refs 4, 5]. Despite the insight brought by such in silico studies, experimental evidence is scarce [refs 6–11]."
Entered by Uri M
ID 112363