Numbr of DNA replication sites in somatic cell

Range 10,000 - 100,000 sites/genome
Organism Human Homo sapiens
Reference Nasheuer HP, Smith R, Bauerschmidt C, Grosse F, Weisshart K. Initiation of eukaryotic DNA replication: regulation and mechanisms. Prog Nucleic Acid Res Mol Biol. 2002 72: 41-94. p.42 top paragraphPubMed ID12206458
Comments p.42 top paragraph:"Because of the size of eukaryotic genomes, chromosomal duplication is accomplished in a multiparallel process. In human somatic cells between 10,000 and 100,000 parallel synthesis sites are present. This raises fundamental problems for eukaryotic cells to coordinate the start of DNA replication at each origin and to prevent replication of already duplicated DNA regions."
Entered by Uri M
ID 111769