| Range |
~0.3 – 1 µm/s
|
| Organism |
Eukaryotes |
| Reference |
Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron. 2012 Sep 6 75(5):762-77. doi: 10.1016/j.neuron.2012.08.019. p.770 right column 4th paragraphPubMed ID22958818
|
| Primary Source |
MacAskill, A.F., Atkin, T.A., and Kittler, J.T. (2010). Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses. Eur. J. Neurosci. 32, 231–240. doi: 10.1111/j.1460-9568.2010.07345.x. & Sheng, Z.-H., and Cai, Q. (2012). Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13, 77–93. doi: 10.1038/nrn3156.PubMed ID20946113, 22218207
|
| Comments |
p.770 right column 4th paragraph:"Mitchondria are formed at the soma. ATP synthesized here would take over 2 min to diffuse to the end of a 200-µm-long dendrite, and ~10 years to diffuse to the end of a 1-m-long axon, preventing rapid adaptation of the ATP supply in response to changing pre- and postsynaptic activity. Instead, therefore, mitochondria are transported long distances around neurons by kinesin and dynein motors, moving on microtubule tracks at ~0.3–1 µm/s. This has been reviewed extensively by [primary sources], who provide more detail
on the following points." |
| Entered by |
Uri M |
| ID |
111658 |