| Comments |
p.763 right column bottom paragraph:"For a synapse with a single release site (e.g., to the orange cell
in Figure 3), if each time a presynaptic action potential arrives
a vesicle is released with probability p, then for p < 1 information
is lost during synaptic transmission." p.766 right column top paragraph:" Figure 3E (red lines) predicts that the optimal release probability is lower the more synapses that a single axon makes onto the same postsynaptic neuron. Strikingly, just such a relationship between release probability and number of release sites has been reported by Hardingham et al. (2010) (their Figure 7C) for cortical synapses and Branco et al. (2008) (their Figure 2D) for hippocampal synapses, with a mean release probability of ~0.7 at connections with a single release site declining to ~0.25–0.4 for connections with 4 release sites and to ~0.1 at connections with ~10 release sites." |