| Range |
naive lymphocytes 3.5 years: memory lymphocytes 22 weeks: Table - link
|
| Organism |
Human Homo sapiens |
| Reference |
Mclean AR, Michie CA. In vivo estimates of division and death rates of human T lymphocytes. Proc Natl Acad Sci U S A. 1995 Apr 25 92(9):3707-11. abstract, p.3710 table 1 & p.3711 left column top paragraphPubMed ID7731969
|
| Method |
Abstract:"[Investigators] present data on the decay, after radiotherapy, of naive and memory human T lymphocytes with stable chromosome damage. These data are analyzed in conjunction with existing data on the decay of naive and memory T lymphocytes with unstable chromosome damage and older data on unsorted lymphocytes." |
| Comments |
Abstract:"The analyses yield in vivo estimates for some life-history parameters of human T lymphocytes. Best estimates of proliferation rates have naive lymphocytes dividing once every 3.5 years and memory lymphocytes dividing once every 22 weeks. It appears that memory lymphocytes can revert to the naive phenotype, but only, on average, after 3.5 years in the memory class." p.3711 left column top paragraph:"Not only
can [investigators] confirm that primed T lymphocytes divide more often
than unprimed (refs 7, 14), but [investigators] can say that, on average, the
primed T lymphocytes in a person's body divide once every 22 weeks whereas the unprimed lymphocytes divide once every 3.5 years." |
| Entered by |
Uri M |
| ID |
111622 |