10e6 ATP molecules
Range: 480-800 10e6 ATP molecules
||Rat Rattus norvegicus
||Hallermann, S., de Kock, C.P.J., Stuart, G.J., and Kole, M.H.P. (2012). State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nat Neurosci. 2012 Jun 3 15(7):1007-14. doi: 10.1038/nn.3132. range given in p.1007 right column 2nd paragraph & p.1013 right column top paragraphPubMed ID22660478
||Modeling of L5 cortical neurons in the Rat based on measurements from male Wistar rats (3–5 weeks of age) acute slice preparations. "Using an in vivo–labeled and fully reconstructed thick-tufted cortical L5 pyramidal neuron, [investigators] estimated that action potential propagation into the dendrites and the axon consumed ~90% of the total action potential energy budget. In terms of ATP consumption, the total cost per action potential was observed to range from ~480 to ~800×10^6 ATP molecules, depending on cell morphology. Finally, [they] found that excess axonal Na+ influx was critical for action potential conduction at high frequencies, revealing a trade-off between energy minimization and conduction reliability."
||"Using models of L5 pyramidal neurons from in vivo recordings, containing the complete three-dimensional axonal and dendritic tree, [investigators] directly calculated that the total quantity of ATP molecules required to restore the Na+ and K+ gradient after one action potential is between ~480 and ~800 × 10^6 ATP molecules for average thick- and slender-tufted L5 neurons, respectively (Fig. 6)." Note-value of 6E+8ATP not found in text