Fraction of point mutations to DNA coding sequence that are synonymous

Value 20.4 %
Organism Generic
Reference Barrick et al., (2009). Genome evolution and adaptation in a long-term experiment with Escherichia coli. Nature 461, 1243–1247. p.1246 left column paragraph above bottom & bottom paragraphPubMed ID19838166
Method "The fact that no synonymous mutations fixed in the first 20,000 generations is consistent with the low point-mutation rate in E. coli and population-genetic theory if those mutations are selectively neutral. According to theory, the expected rate of neutral substitutions equals the rate of neutral mutations [ref 12] . [Researchers] calculate an upper bound for the mutation rate from the Poisson distribution, which specifies a 5% chance that no synonymous substitutions would occur even if three were expected. That upper bound corresponds to a mutation rate of 1.6×10^-10 per bp per generation given 20,000 generations, a genome length of 4.63×10^6 bp, and the fact that 20.4% of all possible point mutations are synonymous."
Comments "This inferred rate lies between earlier estimates from mutation studies [Drake 1991 PMID 1831267] and comparative analyses of E. coli and Salmonella enterica [Ochman et al., 1999 PMID 10535975] ." Based on the E. coli translation table.
Entered by Avi Flamholz
ID 111167