| Comments |
"In each replication fork, a complex with two DNA polymerases replicates the two DNA strands. The pace of the replication fork varies significantly between bacteria. For example, in E. coli the fork progresses at ~1000 nt/s ,in Pyrococcus abyssi at ~300 nt/s (Myllykallio et al., 2000) and in Mycoplasma capricolum at ~100 nt/s (Seto & Miyata, 1998). Thus
although the
M. capricolum
genome is seven times smaller
than that of
E. coli
, it takes longer to be replicated...The replication fork moves at about 600–1000 nt/s (primary source), and to duplicate the average
5Mb E. coli chromosome it takes from 40 to 67 min (Bremer & Dennis, 1996)." |