| Range |
2% - 10% non-humans: 20% humans %
|
| Organism |
Mammals |
| Reference |
Herculano-Houzel S. Scaling of brain metabolism with a fixed energy budget per neuron: implications for neuronal activity, plasticity and evolution. PLoS One. 2011 Mar 1 6(3):e17514. doi: 10.1371/journal.pone.0017514. p.1 left columnPubMed ID21390261
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| Primary Source |
[3] Mink JW, Blumenschine RJ, Adams DB (1981) Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis. Am J Physiol 241: 203–212 [5] ety SS (1957) The general metabolism of the brain in vivo. In: Metabolism of the nervous system Richter D, ed. London: Pergamon. pp 221–237. [6] Sokoloff L (1960) The metabolism of the central nervous system in vivo. In: Handbook of Physiology, Section I, Neurophysiology, vol 3 Field J, Magoun HW, Hall VE, eds. Washington DC: American Physiological Society. pp 1843–1864 [7] Rolfe DFS, Brown GC (1997) Cellular energy utilization and molecular origin of standard metabolic rate in mamals. Physiol Rev 77: 731–758. [8] Clarke DD, Sokoloff L (1999) Circulation and energy metabolism of the brain. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD, eds. Philadelphia: Lippincott- Raven. pp 637–669.PubMed ID7282965, 9234964
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| Comments |
"The scaling of brain metabolism has important implications for brain function and evolution. The brain is the third most energy-expensive organ in the human body, ranking in total organ metabolic cost below skeletal muscle and liver only [1]. While the
metabolic needs of most body organs are closely associated with
body size, such that the relative metabolic cost of an organ depends on its relative size [2], the relative metabolic needs of mammalian brains are variable: excluding humans, the relative cost of the vertebrate brain ranges between 2 and 10% of the
whole body metabolic cost [primary source 3]. This is attributable in part to the large variation in relative brain size across species, and in part to the constantly high metabolic activity of the brain, regardless of the behavioral state of the animal [4]. In contrast, the human
brain, at 2% of body mass, consumes about 20% of the whole
body energy budget [primary sources 5–8], even though the specific metabolic rate
of the human brain is predictably low, given its large size [2]." |
| Entered by |
Uri M |
| ID |
110878 |