| Range |
high correlation: hexadecane 0.95 olive oil 0.93 low correlation: octanol 0.75 ether 0.74 unitless
|
| Organism |
Generic |
| Reference |
Walter A, Gutknecht J. Permeability of small nonelectrolytes through lipid bilayer membranes. J Membr Biol. 1986 90(3):207-17. abstract & p.209 right column 2nd paragraph & p.211 table 2PubMed ID3735402
|
| Method |
"Diffusion of small nonelectrolytes through planar lipid bilayer membranes (egg phosphatidylcholine-decane) was examined by correlating [least square regression analysis] the permeability coefficients of 22 solutes with their partition coefficients between water and four organic solvents." |
| Comments |
"High correlations were observed with hexadecane and olive oil (r = 0.95 and 0.93), but not octanol and ether (r = 0.75 and 0.74)...The relationships between log pm [membrane permeability] and log Kp [partition coefficient] are
nearly linear for all four model solvents, but the
more hydrophobic solvents, hexadecane and olive
oil, correlate much better (r = 0.95 and 0.93) than
octanol and ether (r = 0.75 and 0.74)." |
| Entered by |
Uri M |
| ID |
110815 |