kcat of Csk (Tyrosine-protein kinase CSK) for KKKKEEIYFFF peptide

Value 200 min^-1 Range: ±10 min^-1
Organism Unspecified
Reference Sondhi D, Xu W, Songyang Z, Eck MJ, Cole PA. Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism. Biochemistry. 1998 Jan 6 37(1):165-72. p.167 right column 3rd paragraphPubMed ID9425036
Comments "This peptide [KKKKEEIYFFF] proved to be the most potent small peptide substrate yet identified for Csk with kcat=200±10min^-1 and Km=550±100µM with the divalent ion Mn, an overall catalytic efficiency at least 500-fold greater than that of EGQYQPQPG and within a factor of 4 of poly-(Glu,Tyr)."
Entered by Uri M
ID 110572