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P.3066 left column bottom paragraph:"[Investigators’] analysis has, for simplicity’s sake, ignored the diffusion of R* and E*. These additional diffusive processes are similar in effect to an increase in DG and lead to the reduction of the saturation parameter S. Yet, since [their] estimated value of S, based on Table 1 parameters, is in the range of 10–100 and thus is much larger than 1, its reduction—even by a factor of 2 or 3—would not take the system out of the S . 1 regime analyzed above. Note also that in the regime corresponding to this condition, the size of the spot and the peak amplitude of effector activity are independent of diffusivity and are determined by the balance of k1 and kH." Keywords:Rhodopsin,transducing,phosphodiesterase,rod,retina,phototransduction |