Antibody secretory rate of a bone marrow B cells population

Range ~10^8 molecules IgG, IgA or IgM/cell/h
Organism Human Homo sapiens
Reference Hibi T, Dosch HM. Limiting dilution analysis of the B cell compartment in human bone marrow. Eur J Immunol. 1986 Feb16(2):139-45. p.139 right column top paragraphPubMed ID2869953
Method "[Researchers] used limiting dilution (LD) analysis to characterize BM Ig secretors."
Comments "[Researchers'] results suggest that 2 populations of Ig producing BM B lineage cells can be distinguished from a large, third population of B cells unable to secrete Ig under [Researchers'] culture conditions. The first population contains cells producing Ig “spontaneously” in unstimulated cultures. It is small but has very high secretory rates of approximately 10^8 molecules IgG, IgA or IgM/cell/h. If these cells produced their antibody at similar rates in vivo, then their frequencies would suggest that they could provide up to 2/3 of daily synthetic rates for IgG and IgA and 20-30% of the daily whole body IgM production. These cells are nonproliferating and cannot be infected, activated nor transformed with Epstein-Barr virus (EBV)." BM=bone marrow
Entered by Uri M
ID 110223