Mean DNA replication rate

Value 2.9 kb/min Range: 0.5-11 kb/min
Organism Budding yeast Saccharomyces cerevisiae
Reference Sekedat MD, Fenyö D, Rogers RS, Tackett AJ, Aitchison JD, Chait BT. GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome. Mol Syst Biol. 2010 6: 353. doi: 10.1038/msb.2010.8 p.2 left column 3rd paragraphPubMed ID20212525
Primary Source Raghuraman et al., Replication dynamics of the yeast genome. Science. 2001 Oct 5 294(5540):115-21. DOI: 10.1126/science.294.5540.115 p.119 right column bottom paragraphPubMed ID11588253
Method Oligonucleotide microarrays
Comments "A wide range of nucleotide incorporation rates (0.5–11 kb/min) were observed, with a mean of 2.9 kb/min (primary source), whereas a second study reported a comparable mean rate of DNA duplication of 2.8±1.0 kb/min (BNID 110150)." See primary source p.119 right column bottom paragraph:"As with origin activation times, a broad range of fork rates was observed (ref 32 therein), with a mean of 2.9 kb/min and a median of 2.3 kb/min (Fig. 7)."
Entered by Uri M
ID 110149