LD50 (lethal dose, 50%) of clostridial neurotoxins
| Range | 0.1 - 1.0 ng/kg |
|---|---|
| Organism | Mouse Mus musculus |
| Reference | Montecucco C, Schiavo G. Mechanism of action of tetanus and botulinum neurotoxins. Mol Microbiol. 1994 Jul13(1):1-8. p.2 left column bottom paragraphPubMed ID7527117 |
| Comments | "Clostridial neurotoxins bind specifically to nerve cells. Because of the central importance of the nervous system in the physiology and behaviour of vertebrates, this absolute tissue specificity is the basis of their enormous potency. Mouse LD50 (lethal dose, 50%) ranges between 0.1 and 1 ng/kg for the various neurotoxins, but It should be pointed out that the amount of toxin needed to cause death in the wild is probably much lower." |
| Entered by | Uri M |
| ID | 110008 |