Exclusion of glycine-betaine from the Glutamine side chain
| Value | 7.6 cal/mol |
|---|---|
| Organism | bacteria |
| Reference | Borwankar T, Röthlein C, Zhang G, Techen A, Dosche C, Ignatova Z. Natural osmolytes remodel the aggregation pathway of mutant huntingtin exon 1. Biochemistry. 2011 Mar 29 50(12):2048-60. doi: 10.1021/bi1018368. p.2057 left column bottom paragraphPubMed ID21332223 |
| Comments | "GB, however, favored formation of fibrillar aggregates whose phenotype can be explained with the variations in the transfer free energies of Gln side chains: GB is very mildly excluded from the Gln side chain (7.6 cal/mol), indicating little to no changes of Gln solvation by water or by GB." |
| Entered by | Uri M |
| ID | 109636 |