Percent of ARS Consensus Sequences that are functional (out of 12,000 ACS)

Value 3.3 %
Organism Budding yeast Saccharomyces cerevisiae
Reference Cayrou C et al., Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features. Genome Res. 2011 Sep21(9):1438-49 p.1438 left column top paragraphPubMed ID21750104
Primary Source Nieduszynski CA, Knox Y, Donaldson AD. Genome-wide identification of replication origins in yeast by comparative genomics. Genes Dev. 2006 Jul 15 20(14):1874-9 p.1874 left column bottom paragraphPubMed ID16847347
Comments P.1438 left column top paragraph: "In Saccharomyces cerevisiae, Oris are identified by specific DNA elements, called Autonomous Replication Sequences (ARS), which have a common AT-rich 11-bp ARS Consensus Sequence (ACS). However, sequence specificity identifies potential Oris but does not determine their selection. Indeed, of the 12,000 ACS present in S. cerevisiae genome only 400 (3.3%) are functional (primary source)."
Entered by Uri M
ID 109284