Number of base pairs in telomeres lost by normal somatic cells
| Range | 50 to 200 bp/cell division |
|---|---|
| Organism | Eukaryotes |
| Reference | Babizhayev MA, Vishnyakova KS, Yegorov YE. Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous. Fundam Clin Pharmacol. 2011 Apr25(2):139-62. doi: 10.1111/j.1472-8206.2010.00829.x. p.141 right column 2nd paragraphPubMed ID20412312 |
| Primary Source | Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet. 199618(2):173-9. AND Meeker AK, Coffey DS. Telomerase: a promising marker of biological immortality of germ, stem, and cancer cells. A review. Biochemistry (Mosc). 1997 Nov62(11):1323-31. AND Axelrod N. Of telomeres and tumors. Nat Med. 1996 Feb2(2):158-9.PubMed ID8934879, 9467857, 8574955 |
| Comments | "Normal somatic cells lose 50–200 bp of their telomeres per cell division because of the ‘end-replication problem’ and eventually become senescent when their telomeres reach a critically shortened length [primary sources]." |
| Entered by | Uri M |
| ID | 109260 |