| Comments |
"To evaluate the evolutionary consequences of somatic
mutations, it is first instructive to put things on an equal
footing by standardizing the germline mutation rates of
multicellular lineages to a per cell division basis. Such a
comparison shows that although selection has been incapable
of maintaining per generation germline mutation
rates for base substitutions at the levels observed in
microbes, the per cell division rates have been kept low,
and have perhaps even been suppressed in human
(Table 1)." |